Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Table of Contents

Authors and Affiliations

London Tubular Centre, Department of Renal Medicine, University College London, London, UK

Keith Siew, Viola D’Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R. Wan & Stephen B. Walsh
The Institute for Biomedical Sciences (IBS), The George Washington University, Washington, DC, USA

Kevin A. Nestler
Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA

Charlotte Nelson & Sergio Baranzini
Department of Experimental and Translational Medicine, Università Cattolica del Sacro Cuore di Roma, Rome, Italy

Viola D’Ambrosio
Centre for Advanced Biomedical Imaging, University College London, London, UK

Zhongwang Li & Simon Walker-Samuel
Centre for Computational Medicine, University College London, London, UK

Zhongwang Li & Simon Walker-Samuel
Department of Renal Medicine, University College London, London, UK

Vaksha Patel, Omid Sadeghi-Alavijeh & Jasminka Godovac-Zimmermann
Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA

Eliah Overbey, JangKeun Kim, Cem Meydan & Annalise Schweickart
University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

Sanghee Yun
Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

Sanghee Yun, Frederico C. Kiffer & Amelia J. Eisch
School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland

Michael B. Vaughan & Anthony L. Marullo
Tissue Engineering and Biomaterials Group, Ghent University, Ghent, Belgium

Michael B. Vaughan
Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium

Michael B. Vaughan
Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK

Chris Cheshire
Applied Biotechnology Laboratory, The Francis Crick Institute, London, UK

Laura Cubitt, Nourdine Bah & Samuel Rodriques
Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK

Jessica Broni-Tabi, Peter Gordon & Robert A. A. Campbell
Anti-Doping Laboratory Qatar, Doha, Qatar

Maneera Yousef Al-Jaber, Mohammed Al-Maadheed & Vidya Mohamed-Alis
Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA

Valery Boyko, Alison French, Samrawit Gebre, Lauren M. Sanders, Sylvain V. Costes, Eduardo A.C.Almeida & Jonathan M. Galazka
MRC MDU Mouse Biochemistry Laboratory, University of Cambridge, Cambridge, UK

Peter Barker & Keith Burling
Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

Shehbeel Arif
Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

Shehbeel Arif
Department of Medicine—Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA

Fatemeh Afsari, Samuel Border, Nicholas Lucarelli, Sayat Mimar, Ahmed Naglah & Anindya S. Paul
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA

Noah Allen, Margareth Cheng-Campbell, Angela Kubik & Elizabeth Blaber
Centre of Metabolism and Inflammation, University College London, London, UK

Mohammed Al-Maadheed & Vidya Mohamed-Alis
School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Selin Altinok
Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Amanda L. Brown, Colleen M. McCann, Leah Oswalt, Rebekah Sanchez-Hodge & Jonathan C. Schisler
Blue Marble Space Institute of Science, Seattle, WA, USA

Margareth Cheng-Campbell, Lorraine Christine De Oliveira, Lauren M. Sanders & Fathi Karouia
Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA

Lorianna M. Colón
KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA

Lovorka Degoricija, San-huei Lai Polo, Ryan T. Scott, Amanda M. Saravia-Butler & Afshin Beheshti
Department of Medicine, University of Cambridge, Cambridge, UK

Nichola Figg
School of Health, Science and Wellbeing, Staffordshire University, Stoke-on-Trent, UK

Rebecca Finch & Willian A. da Silveira
Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA

Jonathan Foox & Christopher E. Mason
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA

Jonathan Foox & Christopher E. Mason
Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

Pouya Faridi, Hossein Valipour Kahrood, Han-Chung Lee, Ralf Bernd Schittenhelm, Terry Chin Choy Lim Kam Sian, Erwin Tanuwidjaya, Haijian Zhang & Joel Ricky Steele
Physiology, Biophysics & Systems Biology, Weill Cornell Medical College, New York, NY, USA

Nadia Houerbi
Monash Bioinformatics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia

Hossein Valipour Kahrood
Division of Experimental Medicine & Immunotherapeutics (EMIT), Department of Medicine, University of Cambridge, Cambridge, UK

Aleksandra S. Klosinska, Kevin M. O’Shaughnessy & Yasmin
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China

Yinghui Li & Zhongquan Dai
Cornell Center for Immunology, Cornell University, Ithaca, NY, USA

Irina Matei
Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA

Irina Matei
Advanced Sequencing Facility, The Francis Crick Institute, London, UK

Jérôme Nicod, María Rodríguez-Lopez, Hubert Slawinski & Daniel Snell
Federal University of São Paulo (UNIFESP), São Paulo, Brazil

Lorraine Christine De Oliveira
Pediatrics, Weill Cornell Medical College, New York, NY, USA

Laura Ioana Patras
Department of Immunology and Inflammation, Imperial College London, London, UK

Candice Roufosse
Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA

Annalise Schweickart
International Space University, 67400, Illkirch-Graffenstaden, France

Willian A. da Silveira
University Health Network, Toronto, ON, Canada

Julio Sosa
Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA

Marshall Tabetah
Proteomics, King’s College London, London, UK

Xiaoping Yang & Steven Lynham
Department of Medicine-Quantitative Health Section, University of Florida, Gainesville, FL, USA

Pinaki Sarder
Departments of Biomedical Engineering and Electrical and Computer Engineering, University of Florida, Gainesville, FL, USA

Pinaki Sarder
Space Research Within Reach, San Francisco, CA, USA

Fathi Karouia
Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA

Fathi Karouia
Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA

Hossein Fazelinia
Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan

Akira Uruno & Masayuki Yamamoto
Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki, Japan

Dai Shiba
JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki, Japan

Dai Shiba
Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan

Masayuki Yamamoto
Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA

Elizabeth Blaber
Stanley Center for Psychiatric Research, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA

Elizabeth Blaber
Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

Amelia J. Eisch
Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

Masafumi Muratani
Department of Preventative Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, USA

Sara R. Zwart
NASA Johnson Space Center, Houston, TX, USA

Scott M. Smith
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medical College, New York, NY, USA

Christopher E. Mason
The Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA

Christopher E. Mason
Broad Institute, Cambridge, MA, USA

Afshin Beheshti
Space Biosciences Division, Universities Space Research Association (USRA), Washington, DC, USA

Afshin Beheshti

Contributions

K.S., S.B.W. conceived the study and were responsible for project management. A.J.E., A.B., J.M.G., R.T.S., K.S., S.B.W., V.P., M.M., C.E.M. were involved in conceptualisation of the study. M.Y.A.J., V.M.A., F.K., L.C.D.O., L.M.S., H.F., I.M., S.M.S., C.R., S.L., X.Y., E.T., H.C.L., H.V.K., H.Z., J.R.S., P.F., R.B.S., T.C.C.L.K.S., A.B., A.F., J.M.G., L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., R.F., W.A.D.S., C.C., D.S., H.S., J.N., L.C., M.R.L., N.B., S.R., K.A.N., J.C.S., V.D.A., M.B.V., A.G., C.Z., E.R.W., J.B.T., J.G.Z., K.S., M.A.M., P.G., R.A.A.C., S.B.W., S.W.S., V.P., J.S., C.N., S.B., K.B., K.M.O., N.F., P.B., Y., A.N., F.A., N.L., P.S., S.B.2., S.M., A.S., S.R.Z., M.M., A.S.2, C.E.M., C.M., E.O., J.F., J.K., L.I.P., N.H. developed the methodology. L.M.S., A.J.E., F.C.K., L.M.C., D.Z., Y.L., I.M., S.M.S., D.S.2., S.L., X.Y., A.B., A.F., J.M.G., L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., E.A.C.A., A.K., M.C.C., D.S., H.S., J.N., L.C., M.R.L., S.R., J.C.S., A.L.B., C.M.M., L.O., R.S.H., S.A., A.U., M.Y., V.D.A., E.B., A.G., C.Z., E.R.W., J.B.T., K.S., .P.G., R.A.A.C., V.P., Z.L., A.S.K., K.B., N.F., P.B., Y., S.Y., S.R.Z., M.M., A.S.2., C.E.M., C.M., E.O., J.F., J.K., L.I.P., N.H. carried out the experiments and investigation of the samples. M.Y.A.J., V.M.A., F.K., L.C.D.O., L.M.S., S.A.2, H.F., I.M., S.M.S., C.R., D.S.2, S.L., X.Y., E.T., H.C.L., H.V.K., H.Z., J.R.S., P.F., R.B.S., T.C.C.L.K.S., A.B., A.F., J.M.G, L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., M.T., R.F., W.A.D.S., C.C., L.C., N.B., S.R., K.A.N., J.C.S., A.L.B., C.M.M., R.S.H., A.U., M.Y., V.D.A., A.L.M., M.B.V., A.G., C.Z., E.R.W., M.A.M., O.S.A., S.W.S., V.P., C.N., S.B., K.M.O., Y., S.R.Z., M.M., A.S.2., C.E.M., C.M., E.O., J.F., J.K., L.I.P, N.H. contributed to the analysis and interpretation of the results. L.M.S., A.E., F.C.K., L.M.C., D.Z., Y.L., IM, SMS, DS2, A.B., A.F., J.M.G., L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., E.A.C.A., A.K,. M.C.C., J.C.S., L.O., R.S.H., S.A., A.U., M.Y., E.B., S.Y., S.R.Z., M.M., A.S.2., C.E.M., C.M., E.O., J.F., J.K., L.I.P., N.H. provided the study resources. V.D.A., A.G., C.Z., E.R.W., K.S., S.B.W., V.P., Z.L. contributed to the original drafting of the manuscript. M.Y.A.J., V.M.A., F.K., L.C.D.O., L.M.S., A.J.E, F.C.K., S.A.2, H.F., L.M.C., D.Z., Y.L., I.M., S.M.S., C.R., D.S.2., S.L., X.Y., E.T., H.C.L., H.V.K., H.Z., J.R.S., P.F., R.B.S., T.C.C.L.K.S., A.B., A.F., J.M.G., L.D., R.T.S., S.G., S.L.P., S.V.C., V.B., A.S.B., E.A.C.A., M.T., A.K., M.C.C., R.F., W.A.D.S., C.C., D.S., H.S., J.N., L.C., M.R.L., N.B., S.R., K.A.N., J.C.S., L.O., R.S.H., S.A., A.U., M.Y., V.D.A., E.B., A.L.M., M.B.V., A.G., C.Z., E.R.W., J.B.T., J.G.Z., K.S., M.A.M., O.S.A., P.G., R.A.A.C., S.B.W., S.W.S., V.P., Z.L., J.S., C.N., S.B., A.S.K., K.B., K.M.O., N.F., P.B., Y., A.N., F.A., N.L., P.S., S.B.2, S.M., A.S., S.Y., S.R.Z., M.M., A.S.2, C.E.M., C.M., E.O., J.F., J.K., L.I.P., NH provided critical feedback and helped shape the study and edit the manuscript. M.Y.A.J., S.A.2, C.C., K.A.N., J.C.S., V.D.A., M.B.V., A.G., C.Z., E.R.W., K.S., S.B.W., Z.L., C.N., S.B. planned and designed the figures and visualisation of results. V.M.A., F.K., L.M.S., A.J.E., D.Z., S.M.S., D.S.2, S.L., J.R.S., A.B., J.M.G., R.T.S., S.G., S.V.C., A.S.B., W.A.D.S., C.C., J.N., L.C., S.R., J.C.S., M.Y., E.B., M.B.V., K.S., M.A.M., R.A.A.C., S.B.W., S.W.S., V.P., S.B., K.B., P.B., Y., P.S., S.Y., S.R.Z., M.M., C.E.M., E.O., J.K. supervised this project.